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薬物送達システムグループ研究業績

2013年

  • Effective Treatment of an Orthotopic Xenograft Model of Human Glioblastoma Using an EGFR-retargeted Oncolytic Herpes Simplex Virus.
    Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong C-S, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB and Glorioso JC.
    Molecular Therapy 2013, 21(3): 561-9.| doi:10.1038/mt.2012.211
  • Hedgehog Gli3 activator signal augments tumorigenicity of colorectal cancer via upregulation of adherence-related genes.
    Iwasaki H, Nakano K, Shinkai K, Kunisawa Y, Hirahashi M, Oda Y, Onishi H, Katano M.
    Cancer Sci.; 104(3):328-36. doi: 10.1111/cas.12073. Epub 2013.
  • TrkB/BDNF signaling pathway is a potential therapeutic target for pulmonary large cell neuroendocrine carcinoma.
    Odate S, Nakamura K, Onishi H, Kojima M, Uchiyama A, Nakano K, Kato M, Tanaka M, Katano M.
    Lung Cancer;79(3):205-14. doi: 10.1016/j.lungcan.2012.12.004.
  • Block/homo polyplex micelle-based GM-CSF gene therapy via intraperitoneal administration elicits antitumor immunity against peritoneal dissemination and exhibits safety potentials in mice and cynomolgus monkeys.
    Ohgidani M, FurugakiK, ShinkaiK, KunisawaY, Itaka K, KataokaK and Nakano K.
    J Control Release doi: 10.1016/j.jconrel.2013.02.006.

2012年

  • Effective transgene expression without toxicity by intraperitoneal administration of PEG-detachable polyplex micelles in mice with peritoneal dissemination.
    Kumagai M, Shimoda S, Wakabayashi R, Kunisawa Y, Ishii T, Osada K, Itaka K, Nishiyama N, Kataoka K, Nakano K.
    J. Control. Release  2012 in press.

2011年

  • Impaired activities of cyclic adenosine monophosphate-responsive element binding protein, protein kinase A and calcium-independent phospholipase A2 are involved in deteriorated regeneration of cirrhotic liver after partial hepatectomy in rats.
    Zhao G, Wakabayashi R, Shimoda S, Fukunaga Y, Kumagai M, Tanaka M, Nakano K.
    Hepatology Research  2011 Nov;41(11): 1110-9.
  • Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy.
    Herlambang S, Kumagai M, Nomoto T, Horie S, Fukushima S, Oba M, Miyazaki K, Morimoto Y, Nishiyama N, Kataoka K.
    J. Control. Release 2011 Nov 7;155(3): 449-57.
  • Dual blockade of phosphatidylinositol 3’-kinase and mitogen-activated protein kinase pathways overcomes paclitaxel-resistance in colorectal cancer.
    Xu R, Nakano K, Iwasaki H, Kumagai M, Wakabayashi R, Yamasaki A, Suzuki H, Mibu R, Onishi H, Katano M.
    Cancer Letters 2011 Jul 28;306(2): 151-60.
  • Mechanism of HSV infection through soluble adapter-mediated virus bridging to the EGF receptor.
    Nakano K, Kobayashi M, Nakamura K, Nakanishi T, Asano R, Kumagai I, Tahara H, Kuwano M, Cohen JB, Glorioso JC.
    Virology 2011 Apr 25;413(1): 12-18.

2010年

  • Enhanced in vivo magnetic resonance imaging of tumors by PEGylated iron-oxide-gold core-shell nanoparticles with prolonged blood circulation properties.
    Kumagai M, Sarma TK, Cabral H, Kaida S, Sekino M, Herlambang S, Osada K, Kano MR, Nishiyama N, Kataoka K.
    Macromol. Rapid Commun. 2010 Sep 1;31(17): 1521-28.
  • Visible drug delivery by supramolecular nanocarriers directing to single-platformed diagnosis and therapy of pancreatic tumor model.
    Kaida S, Cabral H, Kumagai M, Kishimura A, Terada Y, Sekino M, Aoki I, Nishiyama N, Tani T, Kataoka K.
    Cancer Res. 2010 Sep 15;70(18):7031-41.
  • VEGFR2 is selectively expressed by FOXP3high CD4+ Treg. Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T, Katano M. Eur J Immunol. 2010 Jan;40(1):197-203.
  • Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells. Basaki Y, Taguchi K, Izumi H, Murakami Y, Kubo T, Hosoi F, Watari K, Nakano K, Kawaguchi H, Ohno S, Kohno K, Ono M, Kuwano M. Eur J Cancer. 2010 Mar;46(5):954-65. Epub 2010 Jan 14.
  • A bevel-gear-shaped rotor bearing a double-decker porphyrin complex.
    Ogi S, Ikeda T, Wakabayashi R, Shinkai S, Takeuchi M.
    Chemistry-A European Journal. 2010 Jul 26;16(28):8285-90.

2009年

  • Enhanced magnetic resonance imaging of experimental pancreatic tumor in vivo by block copolymer-coated magnetite nanoparticles with TGF-beta inhibitor.
    Kumagai M, Kano MR, Morishita Y, Ota M, Imai Y, Nishiyama N, Sekino M, Ueno S, Miyazono K, Kataoka K.
    J Control Release. 2009 Dec 16;140(3):306-11.
  • Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer. Kashihara M, Azuma K, Kawahara A, Basaki Y, Hattori S, Yanagawa T, Terazaki Y, Takamori S, Shirouzu K, Aizawa H, Nakano K, Kage M, Kuwano M, Ono M. J Thorac Oncol. 2009 Sep;4(9):1066-74.
  • Enhanced photodynamic cancer treatment by supramolecular nanocarriers charged with dendrimer phthalocyanine.
    Nishiyama N, Nakagishi Y, Morimoto Y, Lai PS, Miyazaki K, Urano K, Horie S, Kumagai M, Fukushima S, Cheng Y, Jang WD, Kikuchi M, Kataoka K.
    J Control Release. 2009 Feb 10;133(3):245-51.
  • A photo-activated targeting chemotherapy using glutathione sensitive camptothecin-loaded polymeric micelles.
    Cabral H, Nakanishi M, Kumagai M, Jang WD, Nishiyama N, Kataoka K.
    Pharm Res. 2009 Jan;26(1):82-92.
  • Supramolecular assemblies of polyaniline through cooperative bundling by a palladium-complex-appended synthetic cross-linker.
    Kaseyama T, Takebayashi S, Wakabayashi R, Shinkai S, Kaneko K, Takeuchi M.
    Chemistry-A European Journal. 2009 Nov 23;15(46):12627-35.
  • Unexpected effects of terminal olefins on a cooperative recognition system that implicate olefin-olefin interactions.
    Wakabayashi R, Ikeda T, Kubo Y, Shinkai S, Takeuchi M.
    Angew Chem Int Ed Engl. 2009;48(36):6667-70.
  • Nanoparticles of hybrid liposomes for the inhibition of breast tumor growth along with apoptosis
    Shimoda S, Ichihara H, Matsumoto Y, Ueoka R.
    Chem. Lett. 2009 Nov 7;(2) 134-5
  • Chemotherapy with hybrid liposomes for human breast tumors along with apoptosis in vivo.
    Shimoda S, Ichihara H, Matsumoto Y, Ueoka R.
    Int J Pharm. 2009 May 8;372(1-2):162-8.
  • 共役系高分子を自在に並べる.
    若林里衣, 竹林新二, 竹内正之.
    現代化学 2008;442:46-52.

2008年

  • Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers. Fujii T, Kawahara A, Basaki Y, Hattori S, Nakashima K, Nakano K, Shirouzu K, Kohno K, Yanagawa T, Yamana H, Nishio K, Ono M, Kuwano M, Kage M. Cancer Res. 2008 Mar 1;68(5):1504-12.

2007年

  • A novel contrast medium detects increased permeability of rat injured carotid arteries in magnetic resonance T2 mapping imaging.
    Imai Y, Kaneko E, Asano T, Kumagai M, Ai M, Kawakami A, Kataoka K, Shimokado K.
    J Atheroscler Thromb. 2007 Apr;14(2):65-71.
  • Iron hydroxide nanoparticles coated with poly(ethylene glycol)-poly(aspartic acid) block copolymer as novel magnetic resonance contrast agents for in vivo cancer imaging.
    Kumagai M, Imai Y, Nakamura T, Yamasaki Y, Sekino M, Ueno S, Hanaoka K, Kikuchi K, Nagano T, Kaneko E, Shimokado K, Kataoka K.
    Colloids Surf B Biointerfaces. 2007 Apr 15;56(1-2):174-81.
  • Toward the alignment of conjugated polymers into anisotropically-ordered structure.
    Wakabayashi R, Kaneko K, Takeuchi M, Shinkai S.
    New Journal of Chemistry. 2007;31(6):790-99.