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レドックス疾患創薬グループ研究業績

2011年度

  • Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase c-dependent activation of nuclear factor-κB. Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Fujii M, Maeda Y, Fujimura Y, Miura D, Hirano K, Takayanagi R. J Biol Chem. 2011 Sep;286(37):32045-53.
  • Effects of the Chinese Yi-Qi-Bu-Shen Recipe extract on brainstem auditory evoked potential in rats with diabetes. Liu DS, Gao W, Lin WW, Hao YY, Zhong LH, Li W, Inoguchi T, Takayanagi R. J Ethnopharmacol. 2011 Sep;137(1):414-20.
  • Biliverdin protects against the deterioration of glucose tolerance in db/db mice. Ikeda N, Inoguchi T, Sonoda N, Fujii M, Takei R, Hirata E, Yokomizo H, Zheng J, Maeda Y, Kobayashi K, Takayanagi R. Diabetologia. 2011 Aug;54(8):2183-91.
  • Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia. Kato TA, Monji A, Yasukawa K, Mizoguchi Y, Horikawa H, Seki Y, Hashioka S, Han YH, Kasai M, Sonoda N, Hirata E, Maeda Y, Inoguchi T, Utsumi H, Kanba S. Schizophr Res. 2011 Jul;129(2-3):172-82.
  • Clinical and experimental evidence for oxidative stress as an exacerbating factor of diabetes mellitus. Takayanagi R, Inoguchi T, Ohnaka K. J Clin Biochem Nutr. 2011 Jan;48(1):72-7.

2010年度

  • Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters. Maeda Y, Inoguchi T, Takei R, Sawada F, Sasaki S, Fujii M, Kobayashi K, Urata H, Nishiyama A, Takayanagi R. Am J Physiol Renal Physiol. 2010 Dec;299(6):F1328-38.
  • Bilirubin and biliverdin protect rodents against diabetic nephropathy by downregulating NAD(P)H oxidase. Fujii M, Inoguchi T, Sasaki S, Maeda Y, Zheng J, Kobayashi K, Takayanagi R. Kidney Int. 2010 Nov;78(9):905-19.
  • Inverse associations of serum bilirubin with high sensitivity C-reactive protein, glycated hemoglobin, and prevalence of type 2 diabetes in middle-aged and elderly Japanese men and women. Ohnaka K, Kono S, Inoguchi T, Yin G, Morita M, Adachi M, Kawate H, Takayanagi R. Diabetes Res Clin Pract. 2010 Apr;88(1):103-10.

2009年度

  • Impact of metabolic syndrome on the progression of Intima-Media Thickening in Japanese–a follow-up study. Matoba Y, Inoguchi T, Suzuki S, Nasu S, Hashimoto T, Yanase T, Nawata H, Takayanagi R. Diabetes Res Clin Pract. 2009 Dec;86(3):e50-3.
  • Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells. Fan B, Ikuyama S, Gu JQ, Wei P, Oyama J, Inoguchi T, Nishimura J. Am J Physiol Endocrinol Metab. 2009 Jul;297(1):E112-23.
  • Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Ishihara N, Nomura M, Jofuku A, Kato H, Suzuki SO, Masuda K, Otera H, Nakanishi Y, Nonaka I, Goto Y, Taguchi N, Morinaga H, Maeda M, Takayanagi R, Yokota S, Mihara K. Nat Cell Biol. 2009 Aug;11(8):958-66.
  • Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population. Takeuchi F, Serizawa M, Yamamoto K, Fujisawa T, Nakashima E, Ohnaka K, Ikegami H, Sugiyama T, Katsuya T, Miyagishi M, Nakashima N, Nawata H, Nakamura J, Kono S, Takayanagi R, Kato N. Diabetes. 2009 Jul;58(7):1690-9.

2008年度

  • Optimal cut points of waist circumference for the clinical diagnosis of metabolic syndrome in the Japanese population. Matoba Y, Inoguchi T, Nasu S, Suzuki S, Yanase T, Nawata H, Takayanagi R. Diabetes Care. 2008 Mar;31(3):590-2.
  • The lack of the C-terminal domain of adipose triglyceride lipase causes neutral lipid storage disease through impaired interactions with lipid droplets. Kobayashi K, Inoguchi T, Maeda Y, Nakashima N, Kuwano A, Eto E, Ueno N, Sasaki S, Sawada F, Fujii M, Matoba Y, Sumiyoshi S, Kawate H, Takayanagi R. J Clin Endocrinol Metab. 2008 Jul;93(7):2877-84.
  • Differential effect of sulfonylureas on production of reactive oxygen species and apoptosis in cultured pancreatic beta-cell line, MIN6. Sawada F, Inoguchi T, Tsubouchi H, Sasaki S, Fujii M, Maeda Y, Morinaga H, Nomura M, Kobayashi K, Takayanagi R. Metabolism. 2008 Aug;57(8):1038-45.
  • High prevalence of peripheral arterial disease diagnosed by low ankle-brachial index in Japanese patients with diabetes: the Kyushu Prevention Study for Atherosclerosis. Maeda Y, Inoguchi T, Tsubouchi H, Sawada F, Sasaki S, Fujii M, Saito R, Yanase T, Shimabukuro M, Nawata H, Takayanagi R. Diabetes Res Clin Pract. 2008 Dec;82(3):378-82.
  • Pycnogenol, an extract from French maritime pine, suppresses Toll-like receptor 4-mediated expression of adipose differentiation-related protein in macrophages. Gu JQ, Ikuyama S, Wei P, Fan B, Oyama J, Inoguchi T, Nishimura J. Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1390-400.
  • Targeting Oxidant Stress as a Strategy for Preventing Vascular Complications of Diabetes and Metabolic Syndrome. McCarty MF, Inoguchi T. In: Pasupuleti, V. K.; Anderson J. W., eds. Nutraceuticals, Glycemic Health & Type2 Diabetes. Iowa: Wiley-Blackwell; 2008: 201-243.

2007年度

  • Mechaniisms of the Antiatherogenic Action of Adiponection. Kobayashi K, Inoguchi T. Molecular Vasc. Dis. Prev. 2007 4: 7-9.
  • Therapeutic angiogenesis by ex vivo expanded erythroid progenitor cells. Sasaki S, Inoguchi T, Muta K, Abe Y, Zhang M, Hiasa K, Egashira K, Sonoda N, Kobayashi K, Takayanagi R, Nawata H. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H657-65.
  • A Japanese Model of Disease Management. Nakashima N, Kobayashi K, Inoguchi T, Nishida D, Tanaka N, Nakazono H, Hoshino A, Soejima H, Takayanagi R, Nawata H. Medinfo. 2007 part2. 2007 129: 1174-8.
  • Pitavastatin ameliorates albuminuria and renal mesangial expansion by downregulating NOX4 in db/db mice. Fujii M, Inoguchi T, Maeda Y, Sasaki S, Sawada F, Saito R, Kobayashi K, Sumimoto H, Takayanagi R. Kidney Int. 2007 Aug;72(4):473-80.
  • Are free radical reactions increased in the diabetic eye? Yamato M, Matsumoto S, Ura K, Yamada K, Naganuma T, Inoguchi T, Watanabe T, Utsumi H. Antioxid Redox Signal. 2007 Mar;9(3):367-73.
  • Relationship between Gilbert syndrome and prevalence of vascular complications in patients with diabetes. Inoguchi T, Sasaki S, Kobayashi K, Takayanagi R, Yamada T. JAMA. 2007 Sep 26;298(12):1398-400.

Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase c-dependent activation of nuclear factor-κB