ここから本文です

メタボリック・プロファイリンググループ研究業績

2015年度

  • Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells.
    Kumazoe M, Fujimura Y, Hidaka S, Kim Y, Murayama K, Takai M, Huang Y, Yamashita S, Murata M, Miura D, Wariishi H, Maeda-Yamamoto M, Tachibana H.
    Sci Rep. 2015 Mar 31;5:9474.
  • GLP-1 analog liraglutide protects against cardiac steatosis, oxidative stress and apoptosis in streptozotocin-induced diabetic rats.
    Inoue T, Inoguchi T, Sonoda N, Hendarto H, Makimura H, Sasaki S, Yokomizo H, Fujimura Y, Miura D, Takayanagi R.
    Atherosclerosis. 2015 Mar 18;240(1):250-259.
  • Small molecule-sensing strategy and technologies for understanding of the functionality of green tea.
    Fujimura Y.
    Biosci Biotechnol Biochem. 2015 Jan;79(5):687-99.
  • Identification of 3-Methylbutanoyl Glycosides in Green Coffea arabica Beans as Causative Determinants for the Quality of Coffee Flavors.
    Iwasa K, Setoyama D, Shimizu H, Seta H, Fujimura Y, Miura D, Wariishi H, Nagai C, and Nakahara K.
    J Agric Food Chem. 2015 Apr 15;63(14):3742-51.
  • Bacterial metabolism in immediate response to nutritional perturbation with temporal and network view of metabolites.
    Yukihira D, Fujimura Y, Wariishi H, Miura D.
    Mol Biosyst. 2015 Sep;11(9):2473-82.
  • Sphingosine Kinase-1 Protects Multiple Myeloma from Apoptosis Driven by Cancer-Specific Inhibition of RTKs.
    Tsukamoto S, Huang Y, Kumazoe M, Lesnick C, Yamada S, Ueda N, Suzuki T, Yamashita S, Kim YH, Fujimura Y, Miura D, Kay NE, Shanafelt TD, Tachibana H.
    Mol Cancer Ther. 2015 Oct;14(10):2303-12.
  • The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis.
    Kiyonari S, Iimori M, Matsuoka K, Watanabe S, Morikawa-Ichinose T, Miura D, Niimi S, Saeki H, Tokunaga E, Oki E, Morita M, Kadomatsu K, Maehara Y, Kitao H.
    Mol Cancer Ther. 2015 Oct;14(10):2332-42.

2014年度

  • A QSPR Study on Structural Properties of Metabolites for Preferred Ionization in MALDI-MS Analysis.
    Yukihira D, Miura D, Fujimura Y, Umemura Y, Yamaguchi S, Funatsu S, Yamazaki M, Ohta T, Inoue H, Shindo M, Wariishi H.
    J Am Soc Mass Spectrom. 2014 Jan;25(1):1-5.
  • Integrated MALDI-MS Imaging and LC-MS Techniques for Visualizing Spatiotemporal Metabolic Dynamics in a Rat Stroke Model.
    Irie M, Fujimura Y, Yamato M, Miura D, Wariishi H.
    Metabolomics. 2014;10(3):473-483.
  • Mass spectrometry-based metabolic profiling of gemcitabine-sensitive and –resistant pancreatic cancer cells.
    Fujimura Y, Ikenaga N, Ohuchida K, Setoyama D, Irie M, Miura D, Wariishi H, Murata M, Mizumoto K, Hashizume M, Tanaka M.
    Pancreas. 2014 Mar;43(2):311-8.
  • Metformin and liraglutide ameliorate high glucose-induced oxidative stress via inhibition of PKC-NAD(P)H oxidase pathway in human aortic endothelial cells.
    Batchuluun B, Inoguchi T, Sonoda N, Sasaki S, Inoue T, Fujimura Y, Miura D, Takayanagi R.
    Atherosclerosis. 2014 Jan;232(1):156-64.
  • Power of isotopic fine structure for unambiguous determination of metabolite elemental compositions: in silico evaluation and metabolomic application.
    Nagao T, Yukihira D, Fujimura Y, Saito K, Takahashi K, Miura D, Wariishi H.
    Anal Chim Acta. 2014 Feb 27;813:70-6.
  • Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease.
    Ohgidani M, Kato TA, Setoyama D, Sagata N, Hashimoto R, Shigenobu K, Yoshida T, Hayakawa K, Shimokawa N, Miura D, Utsumi H, Kanba S.
    Sci Rep. 2014 May 14;4:4957.
  • MALDI Mass Spectrometry Imaging for Visualizing In Situ Metabolism of Endogenous Metabolites and Dietary Phytochemicals.
    Fujimura Y, Miura D.
    Metabolites. 2014 May 9;4(2):319-46.
  • In situ label-free visualization of orally dosed strictinin within mouse kidney by MALDI-MS imaging.
    Kim YH, Fujimura Y, Sasaki M, Yang X, Yukihira D, Miura D, Unno Y, Ogata K, Nakajima H, Yamashita S, Nakahara K, Murata M, Lin IC, Wariishi H, Yamada K, Tachibana H.
    J Agric Food Chem. 2014 Sep 24;62(38):9279-85.

2013年度

  • In situ label-free imaging for visualizing the biotransformation of a bioactive polyphenol.
    Kim YH, Fujimura Y, Hagihara T, Sasaki M, Yukihira D, Nagao T, Miura D, Wariishi H, Saito K, Yamaguchi S, Tanaka H, Yamada K, Tachibana H.
    Sci Rep. 2013 Sep 30;3;2805.
  • Metabolomics reveals that carnitine-palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells.
    Setoyama D, Fujimura Y, Miura D.
    Genes Cells. 2013 Dec;18(12):1107-19.
  • Downregulation of adipose triglyceride lipase in the heart aggravates diabetic cardiomyopathy in db/db mice.
    Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Maeda Y, Hirata E, Fujimura Y, Miura D, Hirano K, Takayanagi R.
    Biochem Biophys Res Commun. 2013 Aug 16;438(1);224-9.
  • High-throughput metabolic profiling of diverse green Coffea Arabica beans identified tryptophan as an universal discrimination factor for immature beans.
    Setoyama D, Iwasa K, Seta H, Shimizu H, Fujimura Y, Miura D, Wariishi H, Nagai C, Nakahara K.
    PLoS One. 2013 Aug 1;8(8);e70098.

2012年度

  • In situ metabolomic mass spectrometry imaging: Recent advances and difficulties.
    Miura D, Fujimura Y, Wariishi H.
    J Proteomics. 2012 Aug 30;75(16):5052-60.
  • Potential Applicability of MALDI-MS for Low-Molecular-Weight Pesticide Determination.
    Madla S, Miura D, Wariishi H.
    Anal Sci. 2012;28(3):301.

2011年度

  • Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars.
    Fujimura Y, Kurihara K, Ida M, Kosaka R, Miura D, Wariishi H, Yamamoto-Maeda M, Nesumi A, Saito T, Kanda T, Yamada K, Tachibana H.
    PLoS ONE. 2011 Aug 10;6(8);e23426.
  • Reduced expression of adipose triglyceride lipase enhances tumor necrosis factor α-induced intercellular adhesion molecule-1 expression in human aortic endothelial cells via protein kinase c-dependent activation of nuclear factor-kB.
    Inoue T, Kobayashi K, Inoguchi T, Sonoda N, Fujii M, Maeda Y, Fujimura Y, Miura D, Hirano K, Takayanagi R.
    J Biol Chem. 2011 Sep 16;286(37);32045-53.
  • Novel fungal phenylpyruvate reductase belongs to d-isomer-specific 2-hydroxyacid dehydrogenase family.
    Fujii T, Shimizu M, Doi Y, Fujita T, Ito T, Miura D, Wariishi H, Takaya N.
    Biochim Biophys Acta. 2011 Jun 13;1814(12);1669-76.
  • Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein.
    Ito R, Sekiguchi M, Setoyama D, Nakatsu Y, Yamagata Y, Hayakawa H.
    J Biochem. 2011 Jun;149(6):731-8.
  • Molecular actions of Escherichia coli MutT for control of spontaneous mutagenesis.
    Setoyama D, Ito R, Takagi Y, Sekiguchi M.
    Mutat Res. 2011 Feb 10;707(1-2):9-14.

2010年度

  • Ultrahighly Sensitive in Situ Metabolomic Imaging for Visualizing Spatiotemporal Metabolic Behaviors.
    Miura D, Fujimura Y, Yamato M, Hyodo F, Utsumi H, Tachibana H, Wariishi H.
    Anal Chem. 2010, 82(23):9789-96.
  • A strategy for the determination of the elemental composition by fourier transform ion cyclotron resonance mass spectrometry based on isotopic peak ratios.Miura D, Tsuji Y, Takahashi K, Wariishi H, Saito K.Anal Chem. 2010 Jul 1;82(13):5887-91.
  • Maternal exposure to dioxin reduces hypothalamic but not pituitary metabolome in fetal rats: a possible mechanism for a fetus-specific reduction in steroidogenesis.Matsumoto Y, Ishida T, Takeda T, Koga T, Fujii M, Ishii Y, Fujimura Y, Miura D, Wariishi H, Yamada H.J Toxicol Sci. 2010;35(3):365-73.
  • MALDI-MS-based high-throughput metabolite analysis for intracellular metabolic dynamics.Yukihira D, Miura D, Saito K, Takahashi K, Wariishi H.Anal Chem. 2010 May 15;82(10):4278-82.
  • Highly sensitive matrix-assisted laser desorption ionization-mass spectrometry for high-throughput metabolic profiling.Miura D, Fujimura Y, Tachibana H, Wariishi H.Anal Chem. 2010 Jan 15;82(2):498-504.
  • TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor.Hong Byun E, Fujimura Y, Yamada K, Tachibana H.J Immunol. 2010 Jul 1;185(1):33-45.
  • Comparisons of uptake and cell surface binding among pyridoxal, pyridoxine, and pyridoxamine in RAW264.7 cells.Kanouchi H, Shibuya M, Tsukamoto S, Fujimura Y, Tachibana H, Yamada K, Oka T.Nutrition. 2010 Jun;26(6):648-52.
  • Parameter optimization by using differential elimination: a general approach for introducing constraints into objective functions.Nakatsui M, Horimoto K, Okamoto M, Tokumoto Y, Miyake J.BMC Syst Biol. 2010 Sep 13;4 Suppl 2:S9.
  • Determining important regulatory relations of amino acids from dynamic network analysis of plasma amino acids.Shikata N, Maki Y, Nakatsui M, Mori M, Noguchi Y, Yoshida S, Takahashi M, Kondo N, Okamoto M.Amino Acids. 2010 Jan;38(1):179-87.

2009年

  • Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids.Lee JH, Tachibana H, Morinaga Y, Fujimura Y, Yamada K.Life Sci. 2009 Mar 27;84(13-14):415-20.
  • Sophisticated framework between cell cycle arrest and apoptosis induction based on p53 dynamics.Hamada H, Tashima Y, Kisaka Y, Iwamoto K, Hanai T, Eguchi Y, Okamoto M.PLoS One. 2009;4(3):e4795.

2008年

  • The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins.Fujimura Y, Umeda D, Yamada K, Tachibana H.Arch Biochem Biophys. 2008 Aug 15;476(2):133-8.
  • Mathematical modeling and sensitivity analysis of G1/S phase in the cell cycle including the DNA-damage signal transduction pathway.Iwamoto K, Tashima Y, Hamada H, Eguchi Y, Okamoto M.Biosystems. 2008 Oct-Nov;94(1-2):109-17.

2007年

  • The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG.Fujimura Y, Umeda D, Yano S, Maeda-Yamamoto M, Yamada K, Tachibana H.Biochem Biophys Res Commun. 2007 Dec 7;364(1):79-85.