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総括責任者 久保千春 九州大学総長
拠点長 片山佳樹
副拠点長 割石博之 井口登與志 市川和洋
拠点長補佐 大和真由実

先端融合医療レドックスナビ研究拠点 国立大学大学法人九州大学

九州大学

市川 和洋 先端融合医療レドックスナビ研究拠点 教授
大和 真由実 先端融合医療レドックスナビ研究拠点 准教授
田村 千尋 先端融合医療レドックスナビ研究拠点 テクニカルスタッフ
白水 直美 先端融合医療レドックスナビ研究拠点 テクニカルスタッフ

日本電子(株)

杉沢 寿志 日本電子株式会社 経営戦略室 副室長
水田 幸男 株式会社JEOL RESONANCE  エキスパート
澤田 政久 日本電子テクノサービス株式会社 顧問
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先端融合医療レドックスナビ研究拠点 国立大学大学法人九州大学

2011年度

  • Takeuchi N, Mitsuyasu H, Nakanishi T, Nishimura S, Shimoto T, Higaki H, Hashizume M, Iwamoto Y: The Orientation of Orthopaedic Metallic Devices Relative to the Frequency-Encoding Gradient Affects Susceptibility Artifacts : An Experiment Using Open MR Imaging. Fukuoka Acta Media 102(5): 185-194, 2011
  • Tomikawa M, Hong J, Akahoshi T, Tsutsumi N, Ohuchida K, Ieiri S, Ohdaira T, Hashizume M: Usefulness of a real-time virtual reality navigation system using an open magnetic resonance imaging: tumor ablation therapy for 50 liver cancers. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 23, 2011, Berlin, Germany
  • Uemura M, Tomikawa M, Nagao Y, Yamashita N, Kumashiro R, Tsutsumi N, Ohuchida K, Ieiri S, Hashizume M: Significance of metacognitive skills for effective training program for laparoscopic surgery. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 23, 2011, Berlin, Germany
  • Ishii H, Uemura M, Matsuoka N, Tomikawa M, Hashizume M, Takanishi A: Objective skill assessment of laparoscopic surgery using a suture simulator. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 23, 2011, Berlin, Germany
  • Oka M, Cho B, Matsumoto N, Hong J, Komune S, Hashizume M: Pre-registered STAMP method for instant registration in image-guided temporal bone surgery. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 25, 2011, Berlin, Germany
  • Lee J, Kinoshita J, Genya U, Daisuke K, Ishii H, Katsuko I, Hashizume M, Takanishi A: Shape estimation method of flexible endoscope using sensor network in the endoscope handling robot system. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 25, 2011, Berlin, Germany
  • Ohdaira T, Tsutsumi N, Mori M, Jo K, Uemura M, Ieiri S, Hashizume M: Establishment of gastrectomy and hepatectomy by multi-piercing surgery (needle surgery with NOTES) using 3-mm diameter devices. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 25, 2011, Berlin, Germany
  • Suzuki N, Hattori A, Ieiri S, Tomikawa M, Kenmotsu H, Hashizume M: Functions and development of an endoscopic surgery robot system for NOTES and SPS. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 25, 2011, Berlin, Germany
  • Cho B, Oka M, Matsumoto N, Hong J, Hashizume M: Augmented reality of surgical microscope for otologic surgery. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 22-25, 2011, Berlin, Germany
  • Tsutsumi N, Ohdaira T, Tomikawa M, Akahoshi T, Nagao Y, Ohuchida K, Ieiri S, Maehara Y, Hashizume M: Laparoscopic forceps with Doppler probe: a new navigation device for blood vessels. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 22-25, 2011, Berlin, Germany
  • Chung J, Toyoda K, Hong J, Tomikawa M, Hashizume M: Implementation of a 4-DOF master device with a hybrid structure foa a needle insertion task. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 22-25, 2011, Berlin, Germany
  • Toyoda K, Chung J, Murata M, Ieiri S, Tomikawa M, Hashizume M: Inplementation of a MR compatible laparoscope holding robot for laparoscopic hepatectomy using intraoperative MRI. Computer Assisted Radiology and Surgery 25th International Congress and Exhibition, (CARS 2011) June 22-25, 2011, Berlin, Germany

2010年度

  • Laparoscopic splenectomy may be a superior supportive intervention for cirrhotic patients with hypersplenism. Tomikawa M, Akahoshi T, Sugimachi K, Ikeda Y, Yoshida K, Tanabe Y, Kawanaka H, Takenaka K, Hashizume M, Maehara Y. J Gastroenterol Hepatol. 2010; 25(2): 397-402.
  • Successful salvage after necrotizing fasciitis in a lower extremity with hip and knee replacement. Tashiro Y, Shuto T, Yoshida T, Sakamoto A, Yamamoto S,Hashizume M, Iwamoto Y. Current Orthopaedic Practice . 2010; 21(2): 223-225.
  • hTERT-promoter dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells. Onimaru M, Ohuchida K, Mizumoto K, Nagai E, Cui L, Toma H, Takayama K, Matsumoto K, Hashizume M, Tanaka M. Cancer Science. 2010; 101(3): 735-742.
  • Gold nanoparticle-based colorimetric assay for cancer diagnosis. Kang J, Asami Y, Murata M, Kitazaki H, Sadanaga N, Tokunaga E, Shiotani S, Okada S, Maehara Y, Niidome T, Hashizume M, Mori T, Katayama Y. Biosensors and Bioelectronics. 2010; 25: 1869-1874.
  • An effective point-based registration tool for surgical navigation. Hong J, Hashizume M. Surg Endosc. 2010; 24(4): 944-948.
  • Posterior Displacement of the Tibia Increases in Deep Flexion of the Knee. Fukagawa S, Matsuda S, Tashiro Y, Hashizume M, Iwamoto Y. Clin Orthop Relat Res. 2010; 468(4): 1107-1114.
  • Real-Time 3-Dimensional Virtual Reality Navigation System with Open MRI for Breast-Conserving Surgery. Tomikawa M, Hong J, Shiotani S, Tokunaga E, Konishi K, Ieiri S, Tanoue K, Akahoshi T, Maehara Y, Hashizume M. J Am Coll Surg. 2010; 210(6): 927-933.
  • Molecular imaging contrast media for visualization of liver function . Matsuoka Y, Murata M, Fujisaki Y, Narahara S, Shinzato N, Hashizume M. Magnetic Resonance Imaging. 2010; 28(5): 708-715.
  • An assessment of Surgery for Portal Hypertensive Patients Performed at a Single Community Hospital. Tomikawa M, Akahoshi T, Sugimachi K, Ikeda Y, Korenaga D, Takenaka K, Hashizume M, Maehara Y. Surgery Today. 2010; 40 (7): 620-625.
  • Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells. Onimaru M, Ohuchida K, Egami T, Mizumoto K, Nagai E, Cui L, Toma H, Matsumoto K, Hashizume M, Tanaka M. Cancer Gene Therapy. 2010; 17(8): 541-549.
  • Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer . Onimaru M, Ohuchida K, Nagai E, Mizumoto K, Egami T, Cui L, Sato N, Uchino J, Takayama K, Hashizume M. Cancer Letters. 2010; 294 (2): 178-186.
  • Effectiveness of basic endoscopic surgical skill training for pediatric surgeons. Ieiri S, Nakatsuji T, Higashi M, Akiyoshi J, Uemura M, Konishi K, Onimaru M, Ohuchida K, Hong J, Tomikawa M, Tanoue K, Hashizume M, Taguchi T. Pediatr Surg Int. 2010; 26(10): 947-954.
  • General rules for recording endoscopic findings of esophagogastric varices (2nd edition). Tajiri T, Yoshida H, Obara K, Onji M, Kage M, Kitano S, Kokudo N, Kokubu S, Sakaida I, Sata M, Tajiri H, Tsukada K, Nonami T, Hashizume M, Hirota S, Murashima N, Moriyasu F, Saigenji K, Makuuchi H, Oho K, Yoshida T, Suzuki H, Hasumi A, Okita K, Futagawa S, Idezuki Y. Digestive Endoscopy. 2010; 22 (1): 1-9.
  • Current Status and Prerequisites for Natural Orifice Translumenal Endoscopic Surgery (NOTES). Tomikawa M, Xu H, Hashizume M. Surgery Today . 2010; 40(10): 909-916.
  • Electromagnetic thermoablation to treat thrombocytopenia in cirrhotic and hypersplenic rats. Akahoshi T, Hashizume M. Journal of Gastroenterology and Hepatology . 2010; 25(9): 1470-1471.
  • Objective assessment of laparoscopic suturing skills using a motion-tracking system. Yamaguchi S, Yoshida D, Kenmotsu H, Yasunaga T, Konishi K, Ieiri S, Nakashima H, Tanoue K, Hashizume M. Surgical Endoscopy, 2010 (in press)

2009年度

  • A minimally invasive registration method using surface template-assisted marker positioning (STAMP) for image-guided otologic surgery. Matsumoto N, Hong J, Hashizume M, Komune S. Otolaryngol Head Neck Surg. 2009; 140(1): 96-102.
  • Development and validation of a viscoelastic and nonlinear liver model for needle insertion. Kobayashi Y, Onishi A, Hoshi T, Kawamura K, Hashizume M, Fujie M. Int J CARS. 2009; 4(1) : 53-63.
  • The frontal cortex is activated during learning of endoscopic procedures. Ohuchida K, Kenmotsu H, Yamamoto A, Sawada K, Hayami T, Morooka K, Takasugi S, Konishi K, Ieiri S, Tanoue K, Iwamoto Y, Tanaka M, Hashizume M. Surg Endosc. 2009; 23(10): 2296-2301.
  • Effect of Thrombopoietin on Platelet Counts and Liver Regeneration After Partial Hepatectomy in a Rat Model. Shimabukuro R, Kawanaka H, Tomikawa M, Akahoshi T, Konishi K, Yoshida D, Anegawa G, Uehara H, Hashimoto N, Hashizume M, Maehara Y. Surgery Today .2009; 39(12): 1054-1059.
  • Nanoparticles of Adaptive Supramolecular Networks Self-Assembled from Nucleotides and Lanthanide Ions. Nishiyabu R, Hashimoto N, Cho T, Watanabe K,Yasunaga T, Endo A Kaneko K, Niidome T, Murata M, Adachi C, Katayama Y, Hashizume M, Kimizuka N. Journal of the American Chemical Society. 2009; 131(6): 2151-2158.
  • The effect of CyberDome, a novel 3-dimensional dome-shaped display system, on laparoscopic procedures. Ohuchida K, Kenmotsu H, Yamamoto A, Sawada K, Hayami T, Morooka K, Hoshino H, Uemura M, Konishi K,Yoshida D, Maeda T, Ieiri S, Tanoue K,Tanaka M, Hashizume M. Int J CARS. 2009; 4(2) : 125-132.
  • A novel protease activity assay using a protease-responsive chaperone protein. Sao K, Murata M, Fujisaki Y, Umezaki K, Mori T, Niidome T, Katayama Y, Hashizume M. Biochemical and Biophysical Research Communications. 2009; 383: 293-297.
  • Medical Navigation SyStem for Otologic Surgery Based on Hybrid Registration and Virtual Intraoperative Computed Tomography. Hong J, Matsumoto N, Ouchida R, Komune S, Hashizume M. IEEE Trans Biomed Eng. 2009; 56:426-432.
  • Tumor ablation therapy of liver cancers with an open magnetic resonance imaging-based navigation system. Maeda T, Hong J, Konishi K, Nakatsuji T, Yasunakga T, Yamashita Y, Taketomi A, Kotoh K, Enjoji M, Nakashima H, Tanoue K, Maehara Y, Hashizume M. Surg Endosc. 2009; 23: 1048-1053.
  • Quantitative Assessment of Rotatory Instability After Anterior Cruciate Ligament Reconstruction. Tashiro Y, Okazaki K, Miura H, Matsuda S, Yasunaga T, Hashizume M, Nakanishi Y, Iwamoto Y. Am J Sports Med. 2009; 37: 909-916.
  • Molecular design of protein-based nanocapsules for stimulus-responsive characteristics. Sao K, Murata M, Umezaki K, Fujisaki Y, Mori T, Niidome T, Katayama Y, Hashizume M. Bioorg Med Chem. 2009; 17: 85-93.
  • Development of an articulating ultrasonically activated device for laparoscopic surgery. Ogura G, Nakamura R, Muragaki Y, Hashizume M, Iseki H. Surg Endosc. 2009; 23 (9): 2138-2142.
  • Effect of laparoscopic splenectomy on portal hypertensive gastropathy in cirrhotic patients with portal hypertension. Anegawa G, Kawanaka H, Uehara H, Akahoshi T, Konishi K,Yoshida D,Kinjo N, Hashimoto N, Tomikawa M, Hashizume M, Maehara Y. J Gastroenterol Hepatol .2009; 24(9): 1554-1558.
  • Feasibility of a real-time virtual reality navigation system utilizing open magnetic resonance imaging for safe and accurate excision of breast tumor. Tomikawa M, Hong J, Konishi K, Higashi M, Ieiri S, Tanoue K, Shiotani S, Kitao E, Maehara Y, Hashizume M. Int J CARS. 2009; 4(1): S131-S132.

2008年度

  • Molecular design of protein-based nanocapsules for stimulus-responsive characteristics. Sao K, Murata M, Umezaki K, Fujisaki Y, Mori T, Niidome T, Katayama Y, Hashizume M. Bioorganic & Medicinal Chemistry. 2008; 17: 85-93.
  • Real-time magnetic resonance imaging driven by electromagnetic locator for interventional procedure and endoscopic therapy. Hong J, Hata N, Konishi K, Hashizume M. Surg Endosc. 2008; 22(3): 552-556.
  • Intraoperative Magnetic tracker calibration using a magneto-optic hybrid tracker for 3-D ultrasound-based navigation in laparoscopic surgery. Nakamoto M, Nakada K, Sato Y, Konishi K, Hashizume M, Tamura S. IEEE Trans Med Imaging. 2008; 27(2): 255-270.
  • New real-time MR image-guided surgical robotic system for minimally invasive precision surgery. Hashizume M, Yasunaga T, Tanoue K, Ieiri S, Konishi K, Kishi K, Nakamoto H, Ikeda D, Sakuma I, Fuji M, Dohi T. International Journal of Computer Assisted Radiology and Surgery. 2008; 2(6): 317-325.
  • Effectiveness of endoscopic surgery training for medical students using a virtual reality simulator versus a box trainer: a randomized controlled trial. Tanoue K, Ieiri S, Konishi K, Yasunaga T, Okazaki K, Yamaguchi S, Yoshida D, Kakeji Y, Hashizume M. Surg Endosc . 2008; 22(4): 985-990.
  • Investigation of the cause of readmission to the intensive care unit for patients with lung edema or atelectasis. Matsuoka Y, Zaitsu A, Hashizume M. Yonsei Med J . 2008; 49(3): 422-428.
  • Long-term results of balloon-occluded retrograde transvenous obliteration for gastric variceal bleeding and risky gastric varices: A 10-year experience. Akahoshi T, Hashizume M, Tomikawa M, Kawanaka H, Yamaguchi S, Konishi K, Kinjo N, Maehara Y. J Gastroenterol Hepatol . 2008; 23(11): 1702-1709.
  • Impact of network time-delay and force feedback on tele-surgery. Arata J, Takahashi H, Yasunaka S, Onda K, Tanaka K, Sugita N, Tanoue K, Konishi K, Ieiri S, Fujino Y, Ueda Y, Fujimoto H, Mitsuishi M, Hashizume M. Int J CARS . 2008; 3:371-378.
  • Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications. Kinjo N, Kawanaka H, Akahoshi T, Yamaguchi S, Yoshida D, Anegawa G, Konishi K, Tomikawa M, Tanoue K, Hashizume M, Maehara Y. Am J Physiol Gastrointest Liver Physiol . 2008; 295: G1016-G1024.
  • Real-time nonlinear FEM with neural network for simulating soft organ model deformation. Morooka K, Chen X, Kurazume R, Uchida S, Hara K, Iwashita Y, Hashizume M. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv. 2008; 11(2): 742-749.

2007年度

  • Fluid dynamic study on Budd Chiari symdrome: Sensitivity study of vessel reconstruction on image-based simulation. Matsubara M, Watanabe M, Watanabe S, Konishi K, Yamaguchi S, Hashizume M. Journal of Biomechanical Science and Engineering. 2007; 2(2): 69-80.
  • Thoracoscopic Surgical navigation system for cancer locaization in collaprsed lung based on estimation of lung deformation. Nakamoto M, Aburaya N, Sato Y, Konishi K, Yoshino I, Hashizume M, Tamura S. MICCAI . 2007; 2: 68-76.
  • Recovery of respiratory motion and deformation of the liver using laparoscopic freehand 3D ultrasound system. Nakamoto M, Hirayama H, Sato Y, Konishi K, Kakeji Y, Hashizume M, Tamura S. Med image anal . 2007; 11(5): 429-442.
  • Application of Open Source Image Guided Therapy Software in MR-guided Therapies. Hata N, Piper S, Jolesz FA, Tempany CM, Black PM, Morikawa S, Iseki H, Hashizume M, Kikinis R. Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv (MICCAI 2007 10th) . 2007; 10(1): 491-498.
  • Abnormality of the hepatic vein waveforms in cirrhotic patients with portal hypertension and its prognostic implications. Kawanaka H, Kinjo N, Anegawa G, Yoshida D, Migoh S, Konishi K, Ohta M, Yamaguchi S, Tomikawa M, Hashizume M, Maehara Y. J Gastroenterol Hepatol. 2007; 23: 129-136.
  • Construct validity for eye-hand coordination skill on a virtual reality laparoscopic surgical simulator. Yamaguchi S, Konishi K, Yasunaga T, Yoshida D, Kinjo N, Kobayashi K, Ieiri S, Okazaki K, Nakashima H, Tanoue K, Maehara Y, Hashizume M. Surg Endosc . 2007; 21(12): 2253-2257.
  • Current status of Japanese emergency medicine based on a cross-sectional survey of one prefecture. Ezaki T, Yamada T, Yasuda M, Kanna T, Shiraishi K, Hashizume M. Emerg Med Australas. 2007; 19(6): 523-527.
  • Prognosis of Patient with Cardiopulmonary Arrest Transported to Kyushu University Hospital. Noda E, Zaitsu A, Hashizume M, Takahashi S. Fukuoka Acta Media .2007; 98(3): 73-81.
  • A neurosurgical navigation system based on intraoperative tumour remnant estimation. Hong J, Hashizume M. Journal of Robotic Surgery .2007;1(1): 91-97.
  • Fast model-image registration using 2D distance map for surgical navigation system. Iwashita Y, Kurazume R, Konishi K, Nakamoto M, Aburaya N, Sato Y, Hashizume M, Hasegawa T. Advanced Robotices. 2007; 21(7): 751-770.
  • A remote surgery experiment between Japan and Thailand over Internet using a low latency CODEC system. Arata J, Takahashi H, Pitakwatachara P, Warisawa S, Tanoue K, Konishi K, Ieiri S, Shimizu S, Nakashima N, Okamura K, Fujino Y, Ueda Y, Chatiwan P,Mitsuishi M, Hashizume M. 2007 IEEE International Conference on Robotics and Automation. 2007: 953-959.
  • Splenic hemodynamics and decreased endothelial nitric oxide synthase in the spleen of rats with liver cirrhosis. Yamaguchi S, Kawanaka H, Yoshida D, Maehara Y, Hashizume M. Life Sci. 2007; 80(22): 2036-2044.
  • A real-time navigation system for laparoscopic surgery based on three-dimensional ultrasound using magneto-optic hybrid tracking configuration. Konishi K, Nakamoto M, Kakeji Y, Tanoue K, Kawanaka H, Yamaguchi S, Ieiri S, Sato Y, Maehara Y, Tamura S, Hashizume M. International Journal of Computer Assisted Radiology and Surgery. 2007; 2(1): 1-10.
  • MR-compatible laparoscope with a distally mounted CCD for MR image-guided surgery. Yasunaga T, Konishi K, Yamaguchi S, Okazaki K, Hong J, Ieiri S, Nakashima H, Tanoue K, Fukuyo T, Hashizume M. International Journal of Computer Assisted Radiology and Surgery. 2007; 2(1): 11-18.
  • Tele-surgery experiment between Japan and Thailand using high-speed Internet. Arata J, Takahashi H, Pitakwatchara P, Warisawa S, Tanoue K, Konishi K, Ieiri S, Shimizu S, Nakashima H, Okamura K, Fujino Y, Ueda Y, Chotiwan P, Mitsuishi M, Hashizume M. International Journal of Computer Assisted Radiology and Surgery. 2007; 2(Suppl 1): S196-S198.
  • Laparoscopic disconnection of a huge paraumbilical vein shunt for portosystemic encephalopathy. Yamaguchi S, Kawanaka H, Konishi K, Anegawa G, Yoshida D, Kinjo N, Tomikawa M, Hashizume M, Maehara Y. Surg Laparosc Endosc Percutan Tech. 2007; 17(3): 212-214.
  • Assessment of anterolateral rotatory instability in the anterior cruciate ligament - deficient knee using an open magnetic resonance imaging system. Okazaki K, Miura H, Matsuda S, Yasunaga T, Nakashima H, Konishi K, Iwamoto Y, Hashizume M. Am J Sports Med. 2007; 35(7): 1091-1097.
  • Real Time Estimation of Deformig Organs By Neural Network for Endoscopic Surgery Simulator. Morooka K, Masuda H, Kurazume R, Chen X, Uchida S, Hara K, Hashizume M. The First International Symposium on Information and Computer Elements. 2007: 423-428.
  • MRI-guided laparoscopic and robotic surgery for malignancies. Hashizume M. Int J Clin Oncol . 2007; 12(2): 94-98.
  • Emergency medicine in Japan. A look at a current university hospital and the problems faced. Ezaki T, Hashizume M. Emerg Med Australas. 2007; 19(4): 296-299.
  • Nanotechnology and its relevance to the urologist. Gommersall L, Shergill IS, Ahmed HU, Hayne D, Arya M, Patel HRH, Hashizume M, Gill IS. Eur Urol .2007; 52(2): 368-375.
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