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Metabolic profiling research group

Establishment of new discipline of pathological metabolomics on the basis of disease-cytodiagnostic mass spectrometry system

Our group mission is to develop basic technology evaluating biomedical redox state at the level of metabolite and establish a novel advanced methodology/strategy discovering highly reliable biomarkers targeting redox-related diseases. Now, we are actively developing multiple mass spectrometry (MS)-driven metabolite analytical platform. By accelerating interdisciplinary technical fusion in diverse biomedical redox-related research fields, substantial development of drug discovery tool, diagnostic methodology and instrument is in progress, and thus which lead to the establishment of new discipline of pathological metabolomics.

An essence of utilizing metabolome data is to gain a chemical structure-driven understanding of biological phenomena. In view of this concept, we are making efforts to create new technology of pathological metabolomics based on disease-cytodiagnostic mass spectrometry (MS) system toward achievement of clinical application of metabolomics techniques. In attempting to accomplish the research aims outlined above, however, there are several technical problems to be solved, and we have to construct pathology-metabolite association database capable of prompting rapid pathological analysis. Technical problems and solutions for R&D of our proposed metabolomics are shown as follows.

  1. Development of MS imaging with spatial resolution for achievement of pathological and molecular interpretations at multi-cellular level
  2. Improvement of sensitivity for establishment of accurate and precise diagnostic MS system
  3. Improvement of MS resolution for enhancement of molecular coverage and quantitative capacity
  4. Establishment of standard-independent structural estimation system for more global and rapid metabolite identification
    1. Algorism determining chemical composition based on the data obtained by ultra-high resolution MS analysis
    2. High-throughput and high precise MS/MS technique
    3. MS/MS database
  5. Establishment of a high reliable pathology-metabolite association database applicable in both preclinical and clinical settings

Member

Kyushu University

Hiroyuki Wariishi Professor, Faculty of Agriculture, Kyushu University
Daisuke Miura Associate professor, Innovation Center for Medical Redox Navigation, Kyushu University
Yoshinori Fujimura Associate professor, Innovation Center for Medical Redox Navigation, Kyushu University
Satoru Kuhara Professor, Faculty of Agriculture, Kyushu University
Masahiro Okamoto Faculty of Agriculture, Kyushu University, Professor
Mitsuru Shindo Professor, Institute for Materials Chemistry and Engineering
Hirofumi Tachibana Associate professor, Faculty of Agriculture, Kyushu University

SHIMADZU CORPORATION

Yuji Hamazaki SHIMADZU CORPORATION
Deputy General Manager, Collaboration Promotion Department, Analytical & Measuring Instruments Division, Shimadzu Corporation
Hiroki Nakajima SHIMADZU CORPORATION
Assistant Manager, MS Business Unit, Life Science Business Department, Analytical & Measuring Instruments Division, Shimadzu Corporation

Collaboration Company